When you're getting rid of someone or something in your life.
They're so toxic in my life! I'm just going to wash my hands of them and move on.
A more direct way of alerting someone that you are no longer available to whine to.
Mary: Chad cheated on me and I really need someone to talk to.
You: I'm not going to say: "I told you so". I'm washing my hands of this madness.
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