The physical/mental need and craving for drugs a person has never done before. Irritability, anger, depression, and the high risk mindset of wanting to do new, most likely dangerous drugs as soon as possible is the key in diagnosing without-drawals. Often linked with clinical depression.
Person 1: I feel so agitated and pissed! I need to take some pills right now!
Person 2: What? Have you ever even been high before?
Person 1: Well I've smoked a few times, but i hate everything right now and crave hard drugs now!
Person 2: You've never taken any drugs! Calm down you're going through without-drawals.