basically it mean do you want to give me head (brain)
you would say it to someone if you wanted them to give you brain, or would use it to ask if you want someone else too.
jack: you on brain?
girl: yeeeaa
jack: sweet come over here now
Jack: you on brain with Danny?
girl: ooh NO
Jack: safee
girl: i am on brain with you.
Jack: waheyyy
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Meaning, most bitches are braindead bimbos. Just because bimbos spend all their time on social media and listen to terrible music doesn't mean they don't need love.
Son: Katelyn is hot, but dumb as fuck, and we don't share any similar interests.
Dad: You don't fuck brains son.
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A phrase made popular by the 1989 movie 'Heathers' and the 2014 musical of the same name. It is very similar in meaning to 'Are you retarded?'.
Heather Duke: Can I be red?
Heather Chandler: Did you have a brain tumor for breakfast? I'm always red
Heather McNamara: I've been looking forward to this all day!
Heather Duke: Did you have a brain tumor for breakfast?
Used when someone says or does something very stupid
Person 1:Iphone 6 is worth more than the new samsung!
Person 2:Do you have a brain dislocation?