A sudden loss of a large amount of money. It is a corrupted form of the Ukrainian word "zubozhinnia" (ukr. зубóжіння) which means "impoverishment". The word (ukr. зубожиння) became popular as a signature word of the Ukrainian politician Yulia Tymoshenko, who is known for her unique accent. She used it a lot during her time as the prime-minister and later on.
– This lunch costs like a half of my appartment! It's a total zubozhynnia...
– Nah, totally!
– Цей обід коштує як пів моєї хати! Це повне зубожиння...
– І не кажи!