≠ means 'not equal to' and is used for equations that require =, ≈, and ≠.
2 + 4 ≠ 1 6 - 7 ≠ 1 3 x 3 ≠ 8² 9 ÷7 ≠ 3√8 3² ≠ 27.0000000001 √256 ≠ 15