When something in reality scratches the surface of fantasy.
Can be shortened to RLW.
Full-size Gundam mecha resides in Japan somewhere. Is that enough to convince you of Real Life Win?
When you're screwed over (or boned) in the worse possible manner.
When the hull of an intergalactic vessel breaks and you're stuck in a vacuum of space because of it.
Zach Hammond: Be careful, the whole section leads into the vacuum of space......and the Necromorphs have completely taken over the ship!
Isaac Clarke: Oh shittery fuck fuck!