To get belligerently drunk, to the point of blacking out and making choices you may regret
Anyone want to go get knuckled up at Applebee’s with me?
The Act Of Whupping Someone's Ass!
BITCH All In My FACE We Bout 2 KNUCKLE UP In Did Bitch!!!
To masturbate
The act of masturbation
Guy 1: Did you see Stacey?
Guy 2: Yeah, total nipple slip! I'm totally going to knuckle up to that later
When two men choose to engage in mutual masturbation, implementing a "thumb war" grip and jerking themselves off simultaneously, locked at the knuckles.
Since he had a girlfriend, the young man decided to knuckle up with a buddy.