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Random
To do crack or act like doing crack/cocaine.
Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
a girl thats always wanting to get it in
that freshman be tweakin all ova the place. this is her fourth abortion
A meth addict who is stuck doing pointless actions for long periods of time.
After hours of tweak activities, Theodore finally fell asleep.
To stimulate a female's clitoris to the point of a micro-orgasm.
To the theme song tune of 'Kim Possible'. Call me beep me if you wanna tweak me.
To not relax; to not chill; to mimic someone suffering from a unique combination of schizophrenia and terets, presenting a lack of logical thought upon speaking.
Don't tweak bro, relax.
I'm chill man, I never tweak on acid.
Relax for a second, or you might start to tweak.