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Something that is beyond normal amount of crazy; from the Cypress Hill song "Insane in the Brain"
Man 1: I'm getting my spine pierced later.
Man 2: That's insane in the membrane!
defines something beyond crazy
"dude, thats insane in the membrane"
Smoking some of that good chronic and it's hitting you hard making you; insane in the membrane.
"Dude, I was just listening to some Cypress Hill puffin on a fat blunt of OG Kush and now I'm totally insane in the membrane. Shit hit me hard man!"