The specific load of sperm that results in impregnation, and the female becoming a mother, hence "Mother Load". If a woman has had sex more than once during her fertile period, it will be difficult to know exactly which load was the mother load.
I only had sex with her once so I knew the load I busted in her that night was the mother load.
The slurry excreted from a female when she has a massive period.
Wade: The girls were real bitches at tea tonight.
Ian: Must be the mother load.