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To get shot with a sniper rifle or long distance fire.
Most commonly used / heard in Rockstar Games' Grand Theft Auto V Online.
GTA Online DM:
ChuckNorris-RHK picked off boogie1954
BigDick666 picked you off
You picked off NoobGamr231
Something you say to blow off a dude trying to pick you up at a bar. A portmanteau of pick-up and blow-off.
OMFG! This total loser was flirting with me and I just wanted him to shut the fuck up and I said "Sorry, I like boys with tattoos" then he shows me his back and he has a huge like artwork thing on the back! Worst pick-off line ever!
I had a great pick-off line the other day. I was like "sorry, dude. I'd love to talk to you more, but I have some over-ripe fruit at home and I'm itching to bake it into a pie."
A shortened version of "pick your shit up and get the fuck out", an insult similar to "Piss off" but with emphasis to the person's personal belongings and or problems.
Chunky told George to Pick Off! when he was being rude and impolite.
To have male homosexual tendencies
This new guy started at work, and man he is definitely picking fruit off the beef tree!!!
When you've made it to third base with a girl, but you get shut down before either one of you reaches orgasm.
Dude #1: You finally seal the deal with her last night?
Dude #2: Nah, man, I got picked off third.
a prostitute; slut; a person who sleeps with so many guys
Sarah slept with 5 guys. She's such a pick off.
the polite thing to call a Jewish person
Person A: "Is it offensive to call a Jewish person a Jew?"
Person B: "No it's more polite to call them a big nose bagel eater kike kike kike greedy ass kike picking up pennies off the ground kike kike kike matza ball kike soup kosher for kike passover looking ass kike."
Person A: "Oh ok good to know"