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Agitated, anxious, in a tizz. British, Strine, and New Zealand. Cf. panties in a knot.
Don't get your knickers in a twist. The Frogs are just that way.
Upset or stressed about an issue or situation
the criticism from her boss really put her knickers in a twist.
when one gets upset or crazy over something most people think is unimportant
Sally don't get your knickers in a twist over that split milk on the floor, silly Sally!
Skilfully removing your underwear from beneath your swimwear to avoid having to expose yourself in a public space, usually executed on a busy beach where there are no changing rooms.
Jane executed a knicker twist on the beach to avoid baring all to the surrounding beach-goers.