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Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
to be under the influence of methamphetamines
i heard joe's been on one for the past three days
To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.
Tuttie's on one man, he been smokin' ice all week!
Just broke up with my girl and this alone time has me feelin' on one right now.
to be high, faded, to have just smoked weed.
My man James was on one at the party.
1. A game where the only opponents are two people playing against each other.
2. Also know as speedballing; a mixture of cocaine and herion, most often injected.
1. Jack says to Tommy, "Let's play a game of one on one"
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"