Agent Smith Syndrome

A phenomenon occurring in video-games, typically open-world sand-box titles set in urban environments, where otherwise harmless pedestrians suddenly appear to transform into the game's principal antagonist as if in the Matrix.

Assassin's Creed is a textbook example of Agent Smith Syndrome, wherein stealth-murdering some annoying leper in a marketplace crowded with civilians suddenly leads to dozens of guards popping out of nowhere trying to chop off my limbs as if this were the Matrix and they're all Agent Smith.

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