Thizzle is a term meant for a girl who is unloyal and not to be trusted. She may seek validation from her peers on social media by posting "Thirst Traps" or the occasional "booty pic" to lure in unsuspecting men for attention, sex, and or money. Thizzles usually find it hard to keep a relationship because of their hoe-ish ways and may die alone due to their poor romantic and life choices.
Him: Bro my girlfriend cheated on me last night with some dude from the club
Me: Aye man it happens she's a thizzle bro I told you about her