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In doctor who, the doctor gets his hand cut off, then keeps the hand til he needs it and embews his regeneration energy into it and when Donna noble almost dies she touches the severed hand and becomes the doctor donna and has a timelord meta crisis and then when she has a kid part of the meta crisis passes down to her kid
timelord metacrisis is a thing where a human has half time lord energy in their head
Where a human absorbs time lord regeneration energy and becomes half time lord.
Doctor: donna noble will die from the time lord meta crisis inside her head if she ever remembers me