murderize

To obliterate, destroy, or kill something, usually a living being, using excessive violence and/or force.
Another way to describe murderizing something would be overkill.

It is not used often, and even when it is used it is often ridiculous and non serious

Katelyn murderized the cockroaches with her flamethrower

Alex murderized his friend with a dull knife for his satanic ritual.

After being infuriated by her neighbor's actions, Natalie murderized the entire city with nuclear weapons.

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