Lulz is derived from LOL, which stands for Laughing Out Loud. It is a form of Internet slang with orgins residing in Leet talk. In my experience, the connotation is more sarcastic, ridiculing the use of any form of the acronym or the joke being made. In some circles, it is also considered a pun on the word Lull, reinforcing the sarcastic connotation.
"What did the cow say to the horse? Moooove."
"Lulz"
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