Generally used as a strong swear, Asswipe basically means that you are a worthless person used to wipe other people's asses. Thus meaning that you are a worthless piece of shit.
*playing Halo*
Guy 1: Ok, go get the Flag.
Guy 2: Fine. *gets on warthog*
*Guy 2 is killed by a Headshot*
Guy 1: My God! You fucking suck you Asswipe!
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