A high pitch noise; ie, screech, shrill, scream. Generally associated with bestial sounds and eletronic noises, such as oscillating pitch shift, (saw), animalistic high pitch muling/bugleing, or guttural or fry screaming
most likely an anglicization of swedish word skräll; bang, crash, bray, clap
admittedly it could be from skrillex, and skrill maybe associated with skrillexs early dubstep sound, both the high pitch whiny saws, oscillations, sub growling and screeching sounds.
dope skrill, play that shit back.