This phrase is commonly used by ghetto southerners to express how attractive they find someone to be. Instead of just saying that the person is fine, they unnecessarily add the 'up' at the end to make it true southern slang.
Damn mama, you lookin fine up!
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Basically means the same thing as thicc, someone who's not a skinny twig and has an attractive amount of meat on their bones. The only difference is that mostly ghetto southerners use this form of the phrase by adding the unnecessary 'up'.
Damn bo, that man is thicc up.
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