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A pain in the ass, an inconvenience.
Dealing with insurance companies is always a tack in the ass.
An Australian Shepherd (dog breed) that's being an asshole. They are highly energetic and intelligent, so special care must be taken when raising them.
Exercise, train and mentally stimulate your Australian Shepherd or they'll be a constant ausshole.
The worst diarrhea that you can possibly have. Usually caused by food poisoning or exposure to standing water, Medieval Diarrhea is a potentially life-threatening condition that has claimed the lives of countless medieval peasants and lords alike over the centuries. Symptoms include frequent watery and/or bloody diarrhea, stabbing abdominal pains and dizziness/fainting.
Seek medical attention if you develop medieval diarrhea.