A loser is someone who sucks at their sport, activity or hobby of choice. Generally, a loser will lose in the activity they are participating in. A loser is also someone lame or "uncool". In that sense, calling someone a loser would be saying they lost at life (because their life sucks).
"Katie couldn't find any toilet paper in her house. What a loser."
"Daniel was called a loser by his classmates because he wasn't very good at Pokemon"
"I can't finish this project in time. I'm just a loser."
Britta is a verb. To "Britta" something is to screw it up, or make a mistake.
The term originated from the NBC sitcom "Community" which aired from 2009-2015.
The term was first used in Season 3 Episode 5 "Horror Fiction In Seven Spooky Steps".
Annie realized that the tests had been put through the machine upside-down. "She Britta'd it," Jeff sighs.
"I can't believe you Britta'd that season! The show's ratings have gone down significantly."