Use the most powerful method/treatment to any underlying problem or illness when other methods/treatments fails.
Medical Term: I couldn't sleep for a week! Time to start pulling out the big guns!
Problematic Term: Couldn't solve this problem using common methods. Time to start pulling out the big guns!
The idiom "Get your head out of the gutter" means to stop thinking dirty thoughts when someone tells you to.
My Friend: *thinks of dirty thoughts and says it out loud*
Me: Get your head out of the gutter!
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