Short hand for: Go Fuck Your Self/Yourself
Guy being mean to me: Dude shut up, you are't even cool
Me: GFYS
Guy being mean to me: What?
Me: It mans Go Fuck Yourself
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A marijuana cigarette (a.k.a a joint) with the name referencing the widely accepted research that marijuana is a direct cause for schizoid disorders such as schizophrenia.
Dude, get rid of that schizo stick, do you want to be bat shit crazy?
Or
Man, you look like a loser, get rid of that schizo stick before I call the mental institute in advance.