A narrow exclusive circle or group of persons; especially one held together by common interests, views, or purposes. They could be considered your crew. The wolf pack that you run with and tear up the world with and bring people together, one cause at a time.
Kanye is talking about how nobody should mess with his group clique or else they suffer the consequences, such as being rapped about in a his new single.
Ain't nobody messin' with my clique. Ain't nobody fresher than my clique. As I look around, they don't do it like my clique.
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