Describing a person who is so dumb it is sad to say. Comparing his/her brain to a deli ham, which has no wrinkles or curves like the human brain does
Also, comparing ones skill, morals, or ideology to the quality of ham meat. Pork is bad for you & is basically a pigs butt & leg.
When the Lakers dramatically losing a game
Person: Man these mfs ham sandwich. These ain't the Lakers I watched before.