When someone is telling you to stop, but you refuse and challenge them into stopping you; most likely fighting
A: bro can you stop screaming in the bus for no reason
B: then Make me
A: bruh...
Ayo is when people make unfunny sexual joke in class or when they find something suspicious they scream that word all the time
Magic school bus episode:
Girl: gets says something is big
Man1: that kinda sus lol
Man2:hehe
Girl: gets covered in white stuff (yes its real)
Man1:AYO AYO THAT KINDA SUS
Man2: hahahaha
Man3: stop being inappropriate
Rick: sup Ashley
Ashley: Rick to you love me?
Rick: NGL but i love you and i will never let you down..
singing it will out of context will make your friends block you
A: where did you sleep last night?
B: BRO WTF