The main word in a really funny joke from Comedy Central.
Mexican: Hey ese
White Guy: Why are you calling me a term paper?
Mexican: ?
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TMS Syndrome stands for Too Much Swag Syndrome. It is used to sarcastically describe how cool and sexy you'd look when wearing an egotistic and unorthodox outfit.
Guy 1 - *laughs* Look at Billy wearing those sparkly gold sunglasses and tux.
Guy 2 - *sarcastically* Yeah he's rocking that look he looks like he has TMS Syndrome.