For seamen the call of "Harpoon!" is a call of distress when a particularly dangerous sea monster is approaching their vessel. In modern culture this is used by young males to communicate their concern for an inebriated friend being attracted to a morbidly obese or outrageously unattractive female or transvestite.
Travis: "Yo Aaron check out that chick Rick is dancing with."
Aaron: "Oh shit! Harpoon! Harpoon!"
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