Generally used to imply shock that the previous person has posted something either outrageously distasteful or outrageously off topic.
Someone: "I'm glad something bad happened"
Me: "What the actual fuck, dude"
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When something said is so incredibly stupid and tasteless that you have nothing else to respond
Famously attributed to Randy Jackson in American Idol, though he has never said it
13 year old: *Says something edgy and unfunny*
"That's gonna be a no from me, dog"
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Generally used to imply shock that the previous person has posted something either outrageously distasteful or outrageously off topic.
Racist: says something racist
A decent human being: WTF