1)Stands for "Get Your Pen*s Out". (Replace * with "i")
2)May also refer to "Gypsy"
Example 1:
Shawn: Hey Jessica!
Jessica: GYPO
Shawn: O_O
Example 2:
Person 1: Hey look at that GYPO sulking across the street!
Person 2: Yeah, GYPOs these days...
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