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A mixture of the words, "cunt" and, "cuck."
"Eva, you're such a fucking cunk, shut the fuck up you fucking gay ass weeb."
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The Gunio Effect occurs when an annoying event starts to make you more and more miserable over time.
1: "My math teacher assigned extra homework because a few kids were talking. I've lost all happiness because of The Gunio Effect."
2: "God damnit! Every damn time! The fucking Gunio Effect man!"
Similar words: depression anxiety pain mental instability