Derived from the dice game and used as a verb, this word describes a failure to do something correctly, and doubles as a mild expletive. Sometimes combined with "up", similar to a somewhat stronger expletive.
Oh, farkle! I'll have to try that again.
I was going to put this puzzle back together, but I farkled it and just gave up.
Oh, man, I really farkled up this recipe. Let's order pizza.