It means talking incessantly and or to anyone and anything, e.g. girls/guysbwho don't reply, celebrities (via social media) who don't even know if your existence.
o
"That guy never stops talking. He could bark up a tree."
Original coinage:
*replies to 5 story posts with paragraphs, receives only an emoji reaction*
"I could bark up a tree *country accent*"
a creepy dude or a guy who acts like a bitch and gets in his feelings.
"Ima call you Drake since you acting like a lil bitch. Lata Drake."