the term refers to the heavily homosexual movie "Bruno" and his homosexual exploits. You can use it to replace the term "no homo" before or after a sentence that can be confused o taken for a homosexual advance.
It is also an apology or a pardon for what I just said.
"This is mad hard, No Bruno"
"How do you like your nuts prepared, boiled or roasted. No Bruno"
"NO Bruno, pass me the sack of balls over there"
"Put this in your mouth, No Bruno"
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