To explain a situation where you are absolutely exhausted, and don't give a fuck about it no more. You're done and through with it.
"Don't talk to me, I give zero fucks about coronavirus/covid-19"
"2020 such a shitshow, zero fucks"
"Don't tell me how you're always right in everything and I'm to blame, because I give zero fucks about you and what you say/think about me, you harassing asshat"
" Zero Fucks = The midnight sky is the road I'm takin', Head high up in the clouds"
"I'm done caring about a bunch of grown ass clown babies, giving zero fucks"
"If giving you my total two pennies doesn't satisfy you, then gtfo"
"You deserved zero fucks to begin with"