Big Iron

A large-caliber handgun (Preferably a revolver), that is mentioned in the song Big Iron.
The specific Big Iron was used by The Arizona Ranger to take down Texas Red.

This also is referred to in the hit game Fallout: New Vegas, when you as Courier Six shoot Mister House with a Big Iron, ending the game.

"He's here to do some business with the Big Iron on his hip"

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