For men: no.
For women: a fucking mistery.
1) Person 1: "you wanna go out?"
His gf: "no"
Person 1 : *doesn't go out*
His go: "what the fuck. No. What the actual fuck"
2) Person 1: "wanna jerk eachother off ?"
Person 2: "fuck no"
Person 1: *doesn't jerk person 2 off*
Person 2: "good. "