When something, usually minor or irrational, annoys or frustrates you to the point of not being able to let it go. The feeling usually invokes a skin-crawl, murderous eye-twitch, intense cringing or straight up snapping at the source of the titch. Almost like an ick, but not quite.
The sound of Mary chewing her gum is titching me out.
Yes! It always titches me when she does that.
Can you please stop pacing around? It's titching me out.
Are you trying to titch (me out) ?