Worms

Depending on the context, could mean "awesome" or "that sucks."

"That sucks" context:
Teacher: Go pages 50-54 for homework.
Student: Oh, worms.

"Awesome" context:
Hot chick: You're sexy, wanna get laid?
Dude: Wormsssssssssssssssssssssssssssssssssss.

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