Its the creamy mess in a females panties by 5 o'clock in the evening. Some girls are prone to 5 o'clock chowder much earlier in the day. The name is derived from its male counterpart- the 5 o'clock shadow.
Megan: "Lets just change out of our work clothes and go straight to the club and find some cute guys!!"
Robin: "I should definitely shower first and get clean drawers because I have a serious case of 5 o'clock chowder going on down there."