Nicholing

When you do drugs while under the effect of anticoagulants.
Also called "To make a Nichole", even though they are not exactly the same thing, as this is a specific term chicks from the 1920's coined when doing drugs with a very specific anticoagulant called "Mina".

Most old ladies nowadays act like they are such prudes but I bet they fried their brains out Nicholing back in the 20's.