This word is an acronym for "That Hoe Over There." It is used synonymous with slut, hoe, and whore.
"Look at that thot."
"OMG, she is flirting with my boyfriend!"
A cross between a thotie and a bitch; someone who is both slutty and super bitchy.
"I can't fucking stand Karen. She is so mean and she sleeps with literally everyone."
"I know, she is such a fucking thitch."