To make significat change to, particularly in a negative way (ie to eat an obscene portion of food, to do a crappy job on a task, or to injure someone).
That fat ass sure did a number on the hot wings tray. Why did we invite him to this party?
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When one performs an angry dragon and pinchs her noise right before he comes, thus filling her nasal cavity with his load.
Dude, her head nearly exploded when I came and did a Phillerup!