the state in which older women are in when they reach a point in their life in which every single little thing makes them mad/annoyed. Most commonly seen in the workplace where everything seems to be an inconvenience.
Terri: "Have you talked to Mary lately?"
Jenn: "No, she hasn't talked to me in a while after our little argument, she must be having Old Lady Syndrome".
Terri: "That makes sense, she seems to be bothered by everything lately."
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