Absolutely incapable of deeply understanding or having empathy for a particular topic or in general.
I tried to explain Windows files and folders to my mom, but she it totally grokless.
From beginning to end. Refers to the opening/closing acts at Woodstock.
That trip was an unmitigated disaster, from Havens to Hendrix.
Very funny (hilarious) but disturbing.
Howard Stern's interview with Chaz Bono was totally disturbious.