To be Disgusting or foul looking/smelling/in nature . Commonly used to refer to people who do not wash (by choice or otherwise) and therefore do not smell or look clean. Also refers to individuals who are sexuality promiscuous because they are foul in nature.
Oh that girl there, she a skanky hoe. Im skanky, but im not a slut. Oh lord help this little skank(y Bitch).