Getting on your nerves to the point where you want to punch something
Jolene: "I hate that new Katy Perry song."
Susan: "I know, right? It's never off MTV, it's really ripping my knitting."
Getting on your nerves; making you angry
Kevin: "WTF, there's been a commercial break like every ten minutes during this show!"
Fergus: "IKR. It's burning my crumpets."
Kevin: "I'm away to the pub instead."
Fergus: "Word."