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When a girl has a huge pair of tits or ass to the point of either/both of them being disproportionate to the rest of their body.
Man, Sally's got mean Indy Syndrome
When a girl has an ass or pair of tits disproportionate to the rest of the body
That girl is like 5'3" and has an ass big enough to look huge on someone who's 6'2", talk about Indy Syndrome.